Germline-somatic residue synergy reshapes antibody encounter state pathways to enhance HIV 1 recognition
Sangita Kachhap, Yishak Bililign, Jared J. Lindenberger, Carrie Saunders, Priyamvada Acharya, Rory C. Henderson
The paper shows that affinity maturation enhances HIV-1 recognition by reshaping antibody encounter state pathways through germline-somatic residue synergy.
bioRxiv · Mar 27, 2026 · PreprintImmunology