Jared J. Lindenberger

This study uses single-molecule imaging to show peptide inhibitors bind to prefusion viral fusion proteins with varying stoichiometry and rapid kinetics, challenging the canonical prehairpin-intermediate model.

This paper determines the crystal structures of 19b Fab in complex with HIV-1 V3 loop peptides, revealing the epitope and binding mode of the antibody.

This study investigates the structural and antigenic diversity of Henipavirus and Parahenipavirus glycoproteins using cryo-EM and crystal structures, revealing new epitopes and insights for vaccine development.

The paper shows that affinity maturation enhances HIV-1 recognition by reshaping antibody encounter state pathways through germline-somatic residue synergy.

The paper identifies shared maturation pathways of V3-glycan broadly neutralizing antibody lineages in humans and rhesus macaques, revealing convergent mutations and evolution patterns.

This paper designs SARS-CoV-2 RBD immunogens that shift immune responses towards conserved epitopes, improving cross-reactivity against variants.

The paper determines cryo-EM structures of SARS-CoV-2 XBB lineage spike proteins, revealing structural changes that enhance immune evasion and receptor binding.

The paper investigates the binding of Alzheimer's Aβ peptides to exosomes using ITC, finding specific interactions that suggest exosomes as a significant reservoir of these peptides in plasma.