Author

Sangita Kachhap

Duke Medical CenterORCID 0000-0003-2009-1782Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Approach:mechanistic / dynamical model· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

Carrie SaundersiD· 2 shared Priyamvada AcharyaiD· 2 shared Rory C. HendersoniD· 2 shared Yishak BililigniD· 2 shared Amanda NewmaniD· 1 shared Ashliegh WilliamsiD· 1 shared Barton F. HaynesiD· 1 shared Bette KorberiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersImmunology

Carrie SaundersORCID

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2 papers

Recent·Most cited

ImmunologybioRxivPreprintMar 27, 2026

Germline-somatic residue synergy reshapes antibody encounter state pathways to enhance HIV 1 recognition

Sangita Kachhap, Yishak Bililign, Jared J. Lindenberger…·Rory C. Henderson

The paper shows that affinity maturation enhances HIV-1 recognition by reshaping antibody encounter state pathways through germline-somatic residue synergy.

DOI 10.64898/2026.03.26.714541

protein structuremechanistic / dynamical model

𝕏 PostBluesky

ImmunologyNature CommunicationsPeer-reviewedNov 3, 2024

Engineering immunogens that select for specific mutations in HIV broadly neutralizing antibodies

Rory C. Henderson, Kara M. Anasti, Kartik Manne…·Barton F. Haynes

This study uses molecular dynamics simulations to design HIV-1 immunogens that select for specific mutations in broadly neutralizing antibodies.

22 citations

mechanistic / dynamical modeldrug response / drug discovery

𝕏 PostBluesky