Single-cell transcriptomics uncovers that cell-to-cell communication controls p53 activation
Leandro Castellano, Mark E. Robinson, Aleksandra Dabrowska, Niklas Feldhahn, Silvia Ottaviani, Justin Stebbing
The paper uses single-cell RNA sequencing to show that cell-to-cell communication enhances p53 activation in response to chemotherapy, revealing a role for paracrine signaling in treatment response.
bioRxiv · May 30, 2025 · PreprintCancer Biology