Tamás F. Freund

This study shows that hippocampo-septal feedback inhibits the medial septal circuit based on hippocampal activity and movement speed, without being essential for theta rhythm generation.

The paper estimates the absolute numbers of three GABAergic interneuron populations and total GABAergic synapses in the human hippocampus using stereological and electron microscopy techniques.

The paper presents a full-scale in silico model of rat hippocampal CA1 integrating diverse experimental data and validates it through simulations of theta rhythm and other experiments.

The paper quantitatively compares anatomical and physiological properties of OLM and HS hippocampal interneurons using 3D reconstructions, electrophysiology, and modeling.

The paper demonstrates that medial septal pacemaker neurons synchronize their frequencies to generate hippocampal theta oscillations, akin to Huygens' pendulum synchronization.

The paper constructs a network model of hippocampal area CA3 to show that structured synaptic interactions underlie sharp wave-ripples and sequence replay during learning.

HippoUnit provides an open-source Python test suite to systematically compare and evaluate detailed models of rat hippocampal CA1 pyramidal neurons against electrophysiological data.

The paper identifies two distinct basal forebrain cholinergic neuron types with different firing patterns and behavioral roles in mice.

The paper reveals that hippocampal cholinergic terminals form synapses and co-transmit GABA and acetylcholine via distinct vesicles, influencing hippocampal activity and potential therapeutic strategies.