Hippocampo-septal inhibitory feedback controls the medial septal circuit as a function of brain state, pyramidal cell activity and movement speed.
Andor Domonkos, Dániel Schlingloff, B. Király, Litsa Nikitidou Ledri, Márta Jelitai, Gergely F. Turi, Mária Rita Karlócai, Edit Papp, Panna Hegedüs, Gábor Nyíri, Attila I. Gulyás, Tamás F. Freund, Karl A. Deisseroth, Attila Losonczy, Balázs Hangya, Viktor Varga
This study shows that hippocampo-septal feedback inhibits the medial septal circuit based on hippocampal activity and movement speed, without being essential for theta rhythm generation.
bioRxiv · Sep 8, 2026 · PreprintNeuroscience