Huntington's disease-specific mis-splicing captured by human-mouse intersect-RNA-seq unveils pathogenic effectors and reduced splicing factors
Ainara Elorza, Yamile Márquez, Jorge Rubén Cabrera, Jose L. Sanchez‐Trincado, María Santos‐Galindo, Ivó H. Hernández, Juan Ignacio Díaz‐Hernandéz, Ramón García‐Escudero, Manuel Irimia, José J. Lucas
The paper identifies HD-specific mis-splicing using intersect-RNA-seq in human and mouse models, revealing pathogenic splicing factors and effector genes.
bioRxiv · May 11, 2020 · PreprintNeuroscience