Long-term synaptic depression triggers local biogenesis of autophagic vesicles in dendrites and requires autophagic degradation
Emmanouela Kallergi, Akrivi-Dimitra Daskalaki, Evangelia Ioannou, Angeliki Kolaxi, Maria E. Plataki, Per Haberkant, Frank Stein, Mikhail M. Savitski, Kyriaki Sidiropoulou, Yannis Dalezios, Vassiliki Nikoletopoulou
This study shows that long-term synaptic depression triggers local autophagic vesicle biogenesis in dendrites, which is essential for synaptic remodeling and cognitive flexibility.
bioRxiv · Mar 12, 2020 · PreprintNeuroscience