Per Haberkant

Mammalian MemPrep establishes the lipid composition of ER membranes in HEK293T cells

This study characterizes the lipid composition of mammalian ER membranes using MemPrep, showing a common lipid profile across ER subdomains and linking lipid and protein biophysical properties.

A bridge-like lipid transfer protein is critical for generation of invasive stages in malaria parasites

This study identifies PfVPS13L1 as a critical lipid transfer protein in malaria parasites that facilitates lipid transfer from the ER to the inner membrane complex, essential for schizogony.

CXXC5 is a ubiquitinated protein and is degraded by the ubiquitination-proteasome pathway

The paper identifies CXXC5 as a ubiquitinated protein degraded by the ubiquitin-proteasome pathway, independent of cell cycle phases.

UBE3C links ubiquitin signaling to epitranscriptomic control of cortical neurogenesis

The paper shows UBE3C regulates cortical neurogenesis and glial fate through m6A methylation, with mutations disrupting this process and offering therapeutic targets.

iAPEX: Improved APEX-based proximity labeling for subcellular proteomics using an enzymatic reaction cascade

The paper introduces iAPEX, an improved APEX-based proximity labeling method for live-cell proteomics, and applies it to study primary cilia in Xenopus laevis, identifying new ciliary proteins and validating existing ones.

Trifunctional fatty acid derivatives demonstrate the impact of diazirine placement

The paper synthesizes three palmitic acid derivatives with diazirine at different positions and shows that end-position diazirines crosslink distinct protein subsets.

SETD7-mediated lysine monomethylation is abundant on non-hyperphosphorylated nuclear Tau

The paper identifies lysine monomethylation on Tau by SETD7 in human brain tissue and shows its association with nuclear Tau in a mouse model of tauopathy.

Long-term synaptic depression triggers local biogenesis of autophagic vesicles in dendrites and requires autophagic degradation

This study shows that long-term synaptic depression triggers local autophagic vesicle biogenesis in dendrites, which is essential for synaptic remodeling and cognitive flexibility.

Asparagine endopeptidase cleaves tau at N167 after uptake into microglia

The paper identifies a novel tau cleavage site at N167 by AEP in microglia, showing it is part of a proteolytic cascade leading to tau degradation, not accumulation.