A Large Animal Model of Heritable Pulmonary Arterial Hypertension UsingGene-edited BMPR2 Sheep
Sanjeev A. Datar, Nicholas Werry, Austin R Brown, Devon S. Fitzpatrick, Oluwafemi Falade, Josephine F. Trott, Rachel Hutchings, Elena K. Amin, Jessica M. Morgan, Hythem M. Nawaytou, Gail H. Deutsch, Eric G. Johnson, Omar Gonzáles-Viera, Thomas Bishop, Tara Marie Urbano, , Alison Louise Van Eenennaam
This paper develops a gene-edited ovine model of heritable pulmonary arterial hypertension to study BMPR2 mutations and their pathophysiology.
JCI Insight · Jul 14, 2026Peer-reviewedMolecular Biology