Alison Louise Van Eenennaam

This paper develops a gene-edited ovine model of heritable pulmonary arterial hypertension to study BMPR2 mutations and their pathophysiology.

This study generates SOCS2 knock-out sheep using CRISPR-Cas9 ribonucleoprotein electroporation, resulting in compound heterozygotes with large deletions and trace SOCS2 expression.

The paper identifies and compares chromatin accessibility in cattle, pig, and mouse tissues using ATAC-seq, finding species-specific regulatory elements and conservation patterns.