METTL18-mediated histidine methylation on RPL3 modulates translation elongation for proteostasis maintenance
Eriko Matsuura-Suzuki, Tadahiro Shimazu, Mari Takahashi, Kaoru Kotoshiba, Takehiro Suzuki, Kazuhiro Kashiwagi, Yoshihiro Sohtome, Mai Akakabe, Mikiko Sodeoka, Naoshi Dohmae, Takuhiro Ito, Yoichi Shinkai, Shintaro Iwasaki
This study identifies METTL18 as a histidine methyltransferase that modifies RPL3, slowing ribosome translocation on tyrosine codons to aid protein folding and prevent aggregation.
eLife · May 27, 2022Peer-reviewedMolecular Biology