Mari Takahashi

The interferon-stimulated gene product HERC5 inhibits human LINE-1 retrotransposition with an ISGylation-independent mechanism

This study identifies HERC5 as an ISGylation-independent inhibitor of L1 retrotransposition by reducing ORF1p levels and preventing L1 RNP assembly.

Arabidopsis epigenetic factor AS2 attenuates nucleolar stress by camptothecin and establishes leaf polarity by repressing a CDK inhibitor

The paper identifies camptothecin as a chemical modulator of AS2 function in Arabidopsis, showing its role in leaf polarity by regulating nucleolar stress and CDK inhibitor expression.

Pateamine A mediates RNA sequence-selective translation repression by anchoring eIF4A and DDX3 to GNG motifs

This paper identifies pateamine A as a small-molecule compound that selectively represses mRNA translation by anchoring eIF4A and DDX3 to GNG motifs.

METTL18-mediated histidine methylation on RPL3 modulates translation elongation for proteostasis maintenance

This study identifies METTL18 as a histidine methyltransferase that modifies RPL3, slowing ribosome translocation on tyrosine codons to aid protein folding and prevent aggregation.

eIF2B-capturing viral protein NSs suppresses the integrated stress response

This study identifies SFSV NSs as a viral protein that suppresses the integrated stress response by binding to eIF2B and preventing eIF2(P) from inhibiting nucleotide exchange.

A specific eIF4A paralog facilitates LARP1-mediated translation repression during mTORC1 inhibition

The paper shows that eIF4A1, not eIF4A2, facilitates LARP1-mediated translation repression during mTORC1 inhibition by preferentially binding TOP mRNAs.

Structural Basis for eIF2B Inhibition in Integrated Stress Response

The paper determines cryo-EM and crystal structures of eIF2B with phosphorylated and unphosphorylated eIF2 to reveal how eIF2 phosphorylation inhibits eIF2B activity.