Kazuhiro Kashiwagi

This study identifies METTL18 as a histidine methyltransferase that modifies RPL3, slowing ribosome translocation on tyrosine codons to aid protein folding and prevent aggregation.

This study identifies SFSV NSs as a viral protein that suppresses the integrated stress response by binding to eIF2B and preventing eIF2(P) from inhibiting nucleotide exchange.

This study reveals the unidirectional chloride transport mechanism in NM-R3 using TR-SFX, showing conformational changes and halide binding site insights.

The paper shows that eIF4A1, not eIF4A2, facilitates LARP1-mediated translation repression during mTORC1 inhibition by preferentially binding TOP mRNAs.

The paper determines cryo-EM and crystal structures of eIF2B with phosphorylated and unphosphorylated eIF2 to reveal how eIF2 phosphorylation inhibits eIF2B activity.