Chain length defines the spatial segregation and metabolic fate of fatty acids in adipocytes
Dávid Kovács, Romain Gautier, Ana Rita Dias Araújo, Aline Mairal, Abdoul Akim Bello, Lucile Fleuriot, Océane Buvry, Pauline Perne, Delphine Debayle, Camille Fournes-Fraresso, Jacob Bo Hansen, Pierre‐Damien Denechaud, Dominique Langin, Bruno Antonny
This study shows that short- and medium-chain fatty acids are preferentially oxidized within adipocytes rather than released, due to their distinct storage and mobilization dynamics compared to long-chain fatty acids.
bioRxiv · Oct 28, 2025 · PreprintBiochemistry