Antibody-Free Immunopeptide Nano-Conjugates for Brain-Targeted Drug Delivery in Glioblastoma Multiforme
Saurabh Sharma, David Lee, Surjendu Maity, Prabhjeet Singh, Jay Chadokiya, Neda Mohaghegh, Alireza Hassani Najafabadi, Han‐Jun Kim, Ankit Gangrade, Julia Y. Ljubimova, Amanda Kirane, Eggehard Holler
This paper introduces a BBB-penetrating nanoconjugate for glioblastoma treatment that modulates the PD-1/PD-L1 axis without antibodies, showing improved brain accumulation and immune activation in vitro and in vivo.
Bioconjugate Chemistry · Jul 2, 2025Peer-reviewedImmunology