Lerato Majara

A blended genome and exome sequencing method captures genetic variation in an unbiased, high-quality, and cost-effective manner

The paper introduces BGE, a sequencing method that combines low-pass whole genome and deep whole exome data, showing high accuracy and cost-effectiveness for genetic variant discovery.

Genetic structure correlates with ethnolinguistic diversity in eastern and southern Africa

This study examines genetic structure in African populations using ethnolinguistic data, finding that language classifications better capture genetic variation than geography alone.

Low-coverage sequencing cost-effectively detects known and novel variation in underrepresented populations

This study shows low-coverage sequencing is more accurate and cost-effective than GWAS arrays for detecting genetic variation in diverse African populations.

Low generalizability of polygenic scores in African populations due to genetic and environmental diversity

This study evaluates the generalizability of polygenic scores in African populations, finding that PRS accuracy varies significantly across African ancestries and is improved by using ancestrally diverse genetic studies.