Nastassja Koen

Ultra-rare damaging coding variants in 87,959 schizophrenia cases and 150,587 controls implicate 40 genes (16 exome-wide, 24 at 5% FDR), half overlapping autism, developmental delay or bipolar genes.

Across 15 cohorts (birth to 24 years), 20 epigenetic clocks and eight brain age models predicted chronological age modestly, stabilizing by middle childhood; their age residuals were weakly associated.

This study identifies cell type-specific DNA methylation associations with childhood ADHD symptoms using deconvolution and sequencing-based methylation data from peripheral and cord blood.

The paper introduces BGE, a sequencing method that combines low-pass whole genome and deep whole exome data, showing high accuracy and cost-effectiveness for genetic variant discovery.

This review examines the link between epigenetic age deviation and mental health in children, finding mixed results with some studies showing associations but no consistent meta-analysis result.

This review identifies polygenic risk scores (PRS) for neurodevelopmental and mental health disorders associating with adverse outcomes in childhood and adolescence, suggesting shared genetic factors across these conditions.

The paper introduces a pruning and thresholding method for methylation risk scores to improve prediction across multi-ancestry populations, showing better performance than simple thresholding.

This study examines genetic structure in African populations using ethnolinguistic data, finding that language classifications better capture genetic variation than geography alone.

This paper conducts a multi-ancestry GWAS of major depression, identifying 190 loci and 354 genes, with findings showing increased fine-mapping power and bidirectional BMI relationship in European ancestry samples.

This study evaluates the generalizability of polygenic scores in African populations, finding that PRS accuracy varies significantly across African ancestries and is improved by using ancestrally diverse genetic studies.

The paper examines how genetic and environmental factors influence DNA methylation at variably methylated regions in neonatal blood, finding that combined effects best explain methylation variability.

This study identifies genetic overlaps between Tourette Syndrome risk and subcortical brain volumes using GWAS and pleiotropy analysis.

This study conducts the largest GWAS for PTSD, identifying 6 genome-wide significant loci in European and African ancestries and highlighting novel biological pathways.

The paper identifies gene expression signatures in cord blood linked to maternal psychological distress and adverse childhood outcomes, revealing molecular pathways associated with neurodevelopmental disorders.