Targeting TMPRSS2-ERG Fusion-Driven Prostate Cancer using Novel HBS-α-Helicomimics
Sushmita Kundu, Promit Ganguly, Lalnunfela Varte, Shifali Mahajan, Erode N. Prabhakaran, Bushra Ateeq
This study designs and evaluates HBS-constrained alpha-helicomimics targeting ERG-DNA interfaces in TMPRSS2-ERG fusion-driven prostate cancer, showing reduced tumor growth and ERG activity in preclinical models.
bioRxiv · Oct 16, 2026 · PreprintCancer Biology