Bushra Ateeq

This study designs and evaluates HBS-constrained alpha-helicomimics targeting ERG-DNA interfaces in TMPRSS2-ERG fusion-driven prostate cancer, showing reduced tumor growth and ERG activity in preclinical models.

The paper identifies a distal super-enhancer regulating CD47 expression in ovarian cancer, linking it to macrophage-mediated phagocytosis of cancer cells.

The paper shows human ERG oncoprotein represses the LIM-domain binding gene Chip/LDB1 in Drosophila, with implications for prostate cancer, through histone modification and disruption of the Chip-Tailup complex.

This paper develops a computational method to design BH3-mimetic peptides that specifically bind to Mcl-1 or Bcl-XL, validated by cell viability studies.