Andrew D. Hecht

Effects of chemical modulators on enzyme specificity

This study examines how different inhibitors affect enzyme specificity, finding that noncompetitive and mixed inhibitors can alter specificity, while competitive and uncompetitive inhibitors do not.

Kinetic mechanism for fidelity of CRISPR-Cas9 variants

The paper develops a kinetic model of CRISPR-Cas9 substrate selection and cleavage, showing specificity improvements arise from kinetic changes, not binding affinity.

Overlapping stimulons arising in response to divergent stresses in Escherichia coli

The paper shows that E. coli exhibits overlapping stress responses to starvation and lactose toxicity, with distinct gene expression shifts and functional signatures in each condition.