GW McElfresh

Distinct phases of immune system programming during ART-suppressed immunodeficiency virus infection

The paper identifies two distinct phases of immune system changes in ART-suppressed HIV infection using single-cell transcriptomics and proteomics in rhesus macaques.

Early-Life Wildfire Smoke Exposure Is Associated with Long-Term Systemic Immune Remodeling and Epigenetic Reprogramming

This study shows that early-life wildfire smoke exposure in rhesus macaques leads to long-term immune and epigenetic changes, including altered cytokine responses and accelerated epigenetic aging.

Lung Resident T Cells Across the Spectrum of TB Infection and Disease

This study maps human pulmonary T-cell immunity across TB infection/disease using single-cell transcriptomics and functional T-cell cloning, identifying protective immune features and a platform for TB vaccine development.

Antigenic stimulation in conjunction with cytokine is required for mediating IL-17A production in human MAIT cells

This study shows that IL-23 and TCR stimulation together are needed for lung MAIT cells to produce IL-17A, with distinct transcriptional changes observed.

BCG Vaccination at Birth Shapes the TCR Usage and Functional Profile of MR1T Cells at 9 Weeks of Age

This study examines how BCG vaccination at birth affects MR1T cell TCR usage and function in infants, finding increased type I interferon response and a TCR cluster enriched in vaccinated infants.

Human Neonatal MR1T Cells Have Diverse TCR Usage, are Less Cytotoxic and are Unable to Respond to Many Common Childhood Pathogens.

This study compares neonatal and adult MR1T cells, finding neonatal cells have diverse TCR usage, reduced cytotoxicity, and limited pathogen recognition.

Overlapping stimulons arising in response to divergent stresses in Escherichia coli

The paper shows that E. coli exhibits overlapping stress responses to starvation and lactose toxicity, with distinct gene expression shifts and functional signatures in each condition.