Systems BiologybioRxivPreprint
A Mechanistic Model for the HPA Axis Cortisol Paradox in PTSD
Dor Danan, Yaniv Grosskopf, Yoav Hayut…·Uri S. Alon
The paper develops a mechanistic model of the HPA axis to explain the cortisol paradox in PTSD, showing that enhanced GR sensitivity leads to low cortisol with normal ACTH and elevated GR activity.
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