Uri S. Alon

The paper identifies excitability as a unifying design principle in immune circuits, showing its presence in diverse immune subsystems and responses to pathogens and autoimmunity.

This study identifies five classes of endocrine circuits in humans, revealing shared structural and regulatory principles across 43 hormone systems.

The paper develops a mechanistic model of the HPA axis to explain the cortisol paradox in PTSD, showing that enhanced GR sensitivity leads to low cortisol with normal ACTH and elevated GR activity.

The paper examines how subinhibitory concentrations of bacteriostatic and bactericidal antibiotics affect Escherichia coli growth dynamics, revealing distinct temporal responses between the two classes.

This paper estimates that the heritability of human lifespan is about 50% when accounting for extrinsic factors and cutoff age effects, challenging the consensus that genetics has a minor role in lifespan.

The paper identifies five immune response archetypes in mice infected with Plasmodium chabaudi and shows tradeoffs between resistance to different pathogens.

The paper uses a mathematical model of the HPA axis to show that only CRH-targeting drugs can lower long-term cortisol in mood disorders, while other targets fail due to gland-mass compensation.

This study investigates multimer formation in synthetic biology plasmids and presents a strain modification to prevent it.

This paper designs a synthetic stem-cell circuit in E. coli with biphasic fitness to test a theory about mutation resistance in differentiation, finding it robust to mutations and environmental pressures.

This paper models autoimmune disease flares as excitable dynamics, showing how stochastic events trigger relapses and how regulatory cells influence their frequency.

This study compares four rejuvenation strategies in mice and identifies a shared gene expression program involving reduced inflammation and restored fatty acid metabolism, suggesting inflammation as a key upstream factor in aging.

The paper measures damage dynamics in individual E. coli cells under carbon starvation and finds that stochastic noise amplification, not initial conditions, drives lifespan variation, with increasing determinism over time.

The paper maps the dopamine circuit to bacterial chemotaxis, showing it functions as a reward-taxis system using fold-change detection to explain the matching law.

The paper proposes a mathematical model of opponent processes in alcohol addiction, linking changes in HPA gland mass to {beta}-endorphin secretion and addiction vulnerability.

The paper identifies a pre-symptomatic extracellular-matrix signature in colitis models and validates it in human subjects, showing its mediation by neutrophils and monocytes.

The paper analyzes health records to show seasonal patterns in human hormones, finding that effector hormones peak in winter-spring while upstream pituitary hormones peak in summer, suggesting a circannual clock mechanism.

The paper investigates the trade-off between precision and economy in gene expression rates and finds that certain rate combinations are missing due to selective pressures.

The paper introduces a theoretical framework to understand tumor diversity by identifying universal cancer tasks and showing driver mutations influence gene-expression specialization.

The paper derives and tests a growth law for bacterial upshifts, showing that post-shift growth rate is the geometric mean of pre-shift growth and saturating carbon growth, supported by experiments and theoretical analysis.

This study uses fMRI to show that the lateral occipital complex (LOC) distinguishes human-made from random abstract shapes, correlating with beauty and familiarity ratings.