Yoel Toledano

The paper develops a mathematical model and formula (HOMA-C) to quantify beta cell carrying capacity in prediabetes, showing significant variation and its association with diabetes risk.

The paper analyzes lab test dynamics during pregnancy and nonpregnancy to show age-related changes resembling both rejuvenation and aging in different physiological systems.

The paper develops a mechanistic model of the HPA axis to explain the cortisol paradox in PTSD, showing that enhanced GR sensitivity leads to low cortisol with normal ACTH and elevated GR activity.