A Mechanistic Model for the HPA Axis Cortisol Paradox in PTSD
Dor Danan, Yaniv Grosskopf, Yoav Hayut, Yoel Toledano, Keren Doenyas‐Barak, Avi Mayo, Uri S. Alon
The paper develops a mechanistic model of the HPA axis to explain the cortisol paradox in PTSD, showing that enhanced GR sensitivity leads to low cortisol with normal ACTH and elevated GR activity.
bioRxiv · Oct 13, 2025 · PreprintSystems Biology