Juan Manuel Angueyra

This study identifies Tbx2 paralogs as regulators of photoreceptor subtype identity in zebrafish, showing their distinct roles in cone subtype generation and maintenance.

The paper introduces a tool to design light stimuli that predictably alter photoreceptor responses, enabling separation of nonlinearities in phototransduction from downstream circuits.

The paper identifies Nrxn3 as essential for S-cone to SCBC synapse specificity in the mammalian retina using ground squirrel transcriptomes and transgenic mouse models.

The paper identifies transcription factors critical for photoreceptor subtype specification using transcriptomic profiling and CRISPR screening in zebrafish.

The paper develops a biophysical model of cone phototransduction with fast and slow adaptation mechanisms to explain nonlinear responses to natural visual stimuli.