Qiang Chen

The paper identifies the Z-RNA-ZBP1 axis as a driver of Tau-mediated neurodegeneration and shows that ZBP1 inhibition can alleviate cognitive deficits in Tau-transgenic mice.

This study reveals the structural and functional mechanism of Retron-Eco8, a bacterial defense system that uses a holocomplex to cleave phage DNA and inhibit infection.

This study identifies oxidative mtDNA B-Z transitions activating ZBP1 as a key mechanism in APAP-induced liver failure and shows TH107854 can reverse this process.

The paper introduces a tool to design light stimuli that predictably alter photoreceptor responses, enabling separation of nonlinearities in phototransduction from downstream circuits.

This study shows that microglial Piezo1 senses Aβ fibril stiffness, influencing AD pathology by affecting phagocytosis and plaque compaction.