Two sites in the C-terminal β-chain tail mediate interactions of the chaperone clusterin with amyloid beta and other misfolded client proteins
Sandeep Satapathy, Ye Shen, Emma‐Jayne Proctor, Pietro Sormanni, Michele Vendruscolo, Mark R. Wilson
This study identifies two critical sites in the C-terminal β-chain tail of clusterin that mediate its interaction with misfolded proteins, including amyloid β, through experimental and computational approaches.
bioRxiv · Mar 16, 2025 · PreprintBiochemistry