Mark R. Wilson

CD33 and Clusterin Interact Biophysically and Genetically to Modulate Alzheimer Risk

This study shows how non-coding variants in CD33 affect Alzheimer's risk by altering CD33M dimerization and interactions with clusterin and Aβ, impacting microglial function.

Clusterin reverses epitheliopathy, reduces inflammation, and restores goblet cells and corneal nerves in a mouse model of autoimmune dry eye

This study tests clusterin's therapeutic effects in a mouse model of autoimmune dry eye, finding it improves corneal barrier function, nerve density, and goblet cell regeneration while reducing inflammation, comparable to dexamethasone.

Two sites in the C-terminal β-chain tail mediate interactions of the chaperone clusterin with amyloid beta and other misfolded client proteins

This study identifies two critical sites in the C-terminal β-chain tail of clusterin that mediate its interaction with misfolded proteins, including amyloid β, through experimental and computational approaches.