Author

Eric M. Sanford

University of PennsylvaniaORCID 0000-0002-9232-9334Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Organism:human· 3 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:ATAC-seq· 1 Research Focus:benchmarking· 1 Approach:experimental assay· 1

Frequent Co-Authors

Arjun RajiD· 3 shared Benjamin L. EmertiD· 2 shared Yogesh GoyaliD· 2 shared Abhyudai SinghiD· 1 shared Allison CotéiD· 1 shared Carsten MarriD· 1 shared Karun KianiiD· 1 shared Lea SchuhiD· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

9 top collaborators · 25 mutual co-author links

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3 shared papersSystems Biology

Arjun RajORCID

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3 papers

Recent·Most cited

Changes in chromatin accessibility are not concordant with transcriptional changes for single-factor perturbations

Karun Kiani, Eric M. Sanford, Yogesh Goyal, Arjun Raj

The paper evaluates the concordance between chromatin accessibility and transcriptional changes in response to single-factor perturbations, finding that many expression changes occur independently of accessibility changes.

Molecular Systems Biology · Sep 1, 2022Peer-reviewedBioinformatics

Gene regulation gravitates towards either addition or multiplication when combining the effects of two signals

Eric M. Sanford, Benjamin L. Emert, Allison Coté, Arjun Raj

The paper analyzes how gene transcription responds to two signals in human cells, finding that combined responses are mostly additive or multiplicative, with some associations between chromatin accessibility and transcriptional outcomes.

eLife · Dec 7, 2020Peer-reviewedSystems Biology

Gene networks with transcriptional bursting recapitulate rare transient coordinated expression states in cancer

Lea Schuh, Michael Saint-Antoine, Eric M. Sanford, Benjamin L. Emert, Abhyudai Singh, Carsten Marr, Arjun Raj, Yogesh Goyal

The paper shows that transcriptional bursting in gene networks can produce rare coordinated high expression states in cancer cells, which are linked to drug resistance.

Cell Systems · Apr 1, 2020Peer-reviewedSystems Biology