Author

Karun Kiani

University of PennsylvaniaORCID 0000-0002-2779-4870Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 2 Genomics· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:benchmarking· 2 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:scRNA-seq· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

Yogesh GoyaliD· 4 shared Arjun RajiD· 3 shared Benjamin L. EmertiD· 2 shared Ian A. MellisiD· 2 shared Naveen JainiD· 2 shared Allison CotéiD· 1 shared Amanpreet KauriD· 1 shared Ashani T. WeeraratnaiD· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersBioinformatics

Yogesh GoyalORCID

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4 papers

Recent·Most cited

singletCode: synthetic barcodes identify singlets in scRNA-seq datasets and evaluate doublet algorithms

Ziyang Zhang, Madeline E. Melzer, Karun Kiani, Yogesh Goyal

singletCode uses synthetic barcodes to identify singlets in scRNA-seq and evaluates doublet detection methods' performance.

bioRxiv · Aug 4, 2023 · PreprintBioinformatics

Changes in chromatin accessibility are not concordant with transcriptional changes for single-factor perturbations

Karun Kiani, Eric M. Sanford, Yogesh Goyal, Arjun Raj

The paper evaluates the concordance between chromatin accessibility and transcriptional changes in response to single-factor perturbations, finding that many expression changes occur independently of accessibility changes.

Molecular Systems Biology · Sep 1, 2022Peer-reviewedBioinformatics

Cell type determination for cardiac differentiation occurs soon after seeding of human induced pluripotent stem cells

Connie Jiang, Yogesh Goyal, Naveen Jain, Qiaohong Wang, Rachel Truitt, Allison Coté, Benjamin L. Emert, Ian A. Mellis, Karun Kiani, Wenli Yang, Rajan Jain, Arjun Raj

The paper investigates cell type determination during cardiac differentiation of hiPS cells, finding that cell type specification begins shortly after seeding and is cell-autonomous.

Genome biology · Apr 5, 2022Peer-reviewedGenomics

Pre-determined diversity in resistant fates emerges from homogenous cells after anti-cancer drug treatment

Yogesh Goyal, Ian P. Dardani, Gianna T. Busch, Benjamin L. Emert, Dylan F. Fingerman, Amanpreet Kaur, Naveen Jain, Ian A. Mellis, Jingxin Li, Karun Kiani, Mitchell E. Fane, Ashani T. Weeraratna, Meenhard Herlyn, Arjun Raj

The paper shows that resistant fates in cancer cells are predetermined by intrinsic molecular differences, not microenvironmental factors, and can be influenced by drug type and dose.

bioRxiv · Dec 8, 2021 · PreprintSystems Biology