Alexander DeLuna

Widespread Saccharomyces hybridization in agave fermentations arises repeatedly from asymmetric parental diversity

The paper identifies widespread Saccharomyces hybridization in agave fermentations, showing multiple independent origins and asymmetric parental genetic diversity.

Chronological lifespan correlates with virulence within Candida albicans but long lifespan is not restricted to pathogenic Candida species

The paper examines chronological lifespan (CLS) in Candida species, finding that longer CLS correlates with virulence in C. albicans but not across species.

Domestication and deep lineage divergence define two discrete trajectories in Kluyveromyces marxianus

The paper analyzes 178 genomes of Kluyveromyces marxianus to show two distinct evolutionary trajectories within the species, one linked to domestication and the other to deep lineage divergence.

Recurrent introgression and geographical stratification shape Saccharomyces cerevisiae in the Neotropics

The paper analyzes S. cerevisiae isolates from agave fermentation in Mexico, revealing geographical population structure and multiple introgression events in the Neotropics.

Metformin-induced longevity is associated with retrotransposon dynamics in yeast chronological aging

This study identifies retrotransposon dynamics and chromatin regulation as key mechanisms by which metformin extends lifespan in yeast.

SWR1C loss promotes longevity through tRNA-mediated proteostasis

This study identifies tRNA-mediated proteostasis as a mechanism by which SWR1C loss extends longevity in yeast.

Hanseniaspora yeasts from agave fermentations provide insight into intraspecific gene loss

The paper sequenced Hanseniaspora yeasts from agave fermentations, revealing dynamic gene loss across species and functional categories without clear phenotypic consequences.

Ecological divergence of sympatric Saccharomyces species across wild and fermentative environments in the neotropics

This study examines the distribution and ecological divergence of Saccharomyces species in Mexican environments, revealing distinct population structures and dispersal patterns between wild and fermentative habitats.

Regulation of the branched-chain amino acid pathway and its crosstalk to carbon metabolism in yeast

The paper investigates how the branched-chain amino acid (BCAA) pathway is regulated during the diauxic shift in yeast and its impact on carbon metabolism.

Exposing the core genetic drivers of chronological aging in yeast cells

This study identifies core genetic drivers of chronological aging in yeast through meta-analysis and functional screens, revealing Tec1 and mitochondrial machinery as key regulators.

Genomewide identification of subtelomeric silencing factors in budding yeast

The paper introduces a quantitative method to identify subtelomeric silencing factors in budding yeast through genome-wide screening using a dual reporter system.

An Optimized Competitive-Aging Method Reveals Gene-Drug Interactions Underlying the Chronological Lifespan of Saccharomyces cerevisiae

The paper introduces an optimized competitive-aging method to identify gene-drug interactions affecting yeast chronological lifespan, revealing a link between protein glycosylation and metformin-induced lifespan extension.

Genome-Wide Mechanisms of Lifespan Extension by Dietary Restriction in Yeast

The paper identifies 472 yeast gene mutants affected by dietary restriction and highlights Ste12's role in lifespan extension through cell-cycle arrest.

Protein Moonlighting Revealed by Non-Catalytic Phenotypes of Yeast Enzymes

The paper identifies non-catalytic phenotypes in yeast enzymes, suggesting moonlighting activities beyond their annotated functions.