Bernhard Drotleff

This study examines how paternal low protein diet affects mice across generations, revealing sex-specific metabolic changes and intergenerational inheritance patterns.

This study shows that age-related decline in adipose tissue lipolysis reduces disease tolerance to SARS-CoV-2, increasing mortality in older mice and correlating with human COVID-19 severity.

This study uses FRAPPPE to analyze metabolic flux differences between gut Bacteroidota and E. coli, revealing distinct metabolic patterns under anaerobic conditions and in co-metabolism of nucleosides.

This study uses integrative multi-omics analysis to identify disease-associated molecular signatures in lung and muscle tissues of harbour porpoises with poor respiratory health.

This study identifies an ancient monoaminergic system in sponges that coordinates contractility through tryptamine signaling, predating neurons.

HT SpaceM is a high-throughput single-cell metabolomics method that detects small molecules with high reproducibility and identifies cell-type markers and metabolic pathways in diverse cell lines.

This study quantitatively characterizes the lipid composition of extracellular vesicles from multiple cell lines to identify biomarkers and inform EV engineering.

The paper identifies unconjugated bilirubin as a protective metabolite against malaria by inhibiting parasite proliferation and hemozoin formation.

This study identifies adipocyte lipolysis as a critical metabolic process that prevents sepsis in mice by supporting energy metabolism and thermoregulation through insulin signaling, without affecting bacterial burden.

The paper investigates how the branched-chain amino acid (BCAA) pathway is regulated during the diauxic shift in yeast and its impact on carbon metabolism.

METASPACE-ML improves metabolite annotation in imaging mass spectrometry by using machine learning, achieving higher precision and throughput than a rule-based method.

The paper identifies an ancient relaxant-inflammatory response in sponges during deflation, driven by actomyosin relaxation and associated with inflammation-like states.

This study examines changes in progestogen levels and their effects on brain connectivity and mood in women starting or discontinuing oral contraceptives using longitudinal fMRI and behavioral measures.