Author

Mukund Varma

Caris Life Sciences (United States)ORCID 0000-0002-9254-1247Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:batch correction / integration· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Nicolas StranskyiD· 2 shared Agathe PeltieriD· 1 shared Alicia Tran-DieniD· 1 shared Amélie RoehrigiD· 1 shared Benjamin BesseiD· 1 shared Céline VallotiD· 1 shared Christophe MassardiD· 1 shared Claudio NicotraiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCancer Biology

Nicolas StranskyORCID

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2 papers

Recent·Most cited

Cancer BiologybioRxivPreprintApr 2, 2026

Single-cell trajectories in metastatic urothelial carcinoma reveal tumor-immune reprogramming and macrophage-driven resistance to PD-(L)1 blockade

Ronan Flippot, Amélie Roehrig, Julien Vibert…·Yohann Loriot

This study uses single-cell RNA sequencing to analyze metastatic urothelial carcinoma and identifies macrophage-driven resistance to PD-(L)1 blockade as a key mechanism.

DOI 10.64898/2026.03.31.715549

humanscRNA-seq

BioinformaticsbioRxivPreprintNov 26, 2025

Caris-ComBat-seq: Directionally Harmonizing Large-Scale RNA-seq Datasets

Laura M. Richards, Mukund Varma, Noah Spies…·Fred P. Davis

The paper introduces Caris-ComBat-seq, a method to harmonize RNA-seq data by directionally adjusting batches, separating training and adjustment steps, and handling outliers, validated on large tumor datasets.

DOI 10.1101/2025.11.26.690779

humanbulk RNA-seq