Laura M. Richards

The paper introduces Caris-ComBat-seq, a method to harmonize RNA-seq data by directionally adjusting batches, separating training and adjustment steps, and handling outliers, validated on large tumor datasets.

This paper identifies PRMT5 as a regulator of HTT mRNA splicing and alternative polyadenylation, showing that its inhibition reduces full-length HTT protein levels by promoting premature termination and cleavage.

This study compares five data integration methods for single-cell RNA sequencing of cancer samples, finding STACAS and fastMNN most effective in correcting batch effects while preserving biological variability.

CReSCENT provides a web-based toolkit for analyzing scRNA-seq data in cancer research, offering preconfigured pipelines and user-editable workflows for non-experts.