Genetic drivers of repeat expansion disorders localize to 3-D chromatin domain boundaries
James Sun, Linda Zhou, Daniel J. Emerson, Thomas G. Gilgenast, Katelyn R. Titus, Jonathan A. Beagan, Jennifer E. Phillips‐Cremins
The paper identifies that STRs causing repeat expansion disorders are located at 3-D chromatin domain boundaries, which are enriched in CpG islands and may contribute to epigenetic instability.
bioRxiv · Sep 20, 2017 · PreprintGenomics