Linda Zhou

Mosaic H3K9me3 at BREACHes predicts synaptic gene expression associated with fragile X syndrome cognitive severity

The paper identifies H3K9me3 variation at BREACHes in FXS patients and shows it improves prediction of cognitive metrics when combined with FMRP and BREACH gene mRNA levels.

Cohesin-mediated loop anchors confine the location of human replication origins

This study shows that cohesin-mediated loops in G1 phase determine the genomic location of replication origins in S phase by anchoring replication initiation zones.

Spatially coordinated heterochromatinization of distal short tandem repeats in fragile X syndrome

The paper shows that in fragile X syndrome, long-range heterochromatinization of distal synaptic genes with STR instability is reversible by overexpression of a pre-mutation-length CGG tract.

Genetic drivers of repeat expansion disorders localize to 3-D chromatin domain boundaries

The paper identifies that STRs causing repeat expansion disorders are located at 3-D chromatin domain boundaries, which are enriched in CpG islands and may contribute to epigenetic instability.