Jonathan A. Beagan

The paper shows that electrical synapses in C. elegans filter sensory information to guide context-specific behavioral choices by modulating neuronal excitability and integration of temperature stimuli.

The paper shows that cohesin's role in neuronal gene expression depends on chromatin loop length, with longer loops requiring cohesin for full gene expression.

The paper identifies epigenetic changes in neocortical excitatory neurons under chronic stress that contribute to depression-like behaviors in mice.

This paper introduces LADL, a light-activated system to dynamically control chromatin looping, showing it can redirect enhancer-promoter interactions and alter gene expression within four hours.

The paper introduces 5C-ID, a method that improves resolution and reduces noise in chromatin loop detection compared to standard 5C, enabling high-resolution 3D genome maps at lower cost than Hi-C.

The paper identifies that STRs causing repeat expansion disorders are located at 3-D chromatin domain boundaries, which are enriched in CpG islands and may contribute to epigenetic instability.