Thomas G. Gilgenast

Schizophrenia-associated somatic copy number variants from 12,834 cases reveal contribution to risk and recurrent, isoform-specific NRXN1 disruptions

This study identifies somatic copy number variants (sCNVs) in schizophrenia cases, revealing their contribution to risk and specific NRXN1 disruptions.

Acetylated Chromatin Domains Link Chromosomal Organization to Cell- and Circuit-level Dysfunction in Schizophrenia and Bipolar Disorder

The paper identifies acetylated chromatin domains associated with dysfunction in schizophrenia and bipolar disorder by analyzing histone modifications in prefrontal cortex samples.

3DeFDR: Identifying cell type-specific looping interactions with empirical false discovery rate guided thresholding

3DeFDR identifies cell type-specific looping interactions from 5C data by using empirical false discovery rate guided thresholding to reduce false positives.

LADL: Light-activated dynamic looping for endogenous gene expression control

This paper introduces LADL, a light-activated system to dynamically control chromatin looping, showing it can redirect enhancer-promoter interactions and alter gene expression within four hours.

Re-configuration of Chromatin Structure During the Mitosis-G1 Phase Transition

The paper examines how chromatin structures re-establish after mitosis using Hi-C, showing rapid compartment formation and dynamics of CTCF and cohesin binding.

Systematic evaluation of statistical methods for identifying looping interactions in 5C data

This study evaluates statistical methods for identifying chromatin looping interactions in 5C data, comparing their performance across analysis steps and providing a software tool for testing these methods.

Genetic drivers of repeat expansion disorders localize to 3-D chromatin domain boundaries

The paper identifies that STRs causing repeat expansion disorders are located at 3-D chromatin domain boundaries, which are enriched in CpG islands and may contribute to epigenetic instability.