Qingyou Xia

Reversion to the Meta Body Form of Life after Complete Cell Death in Pure Liquid Water

This study shows that after complete cell death of Staphylococcus aureus in pure water, lipid bilayer microspheres containing RNA and proteins form and exhibit dynamic stability, suggesting a simpler form of life called the Meta Body.

High-throughput and genome-scale targeted mutagenesis using CRISPR in a non-model multicellular organism, Bombyx mori

The paper develops a CRISPR-based method to generate a large-scale mutant library in Bombyx mori, identifying genes involved in phenotypic changes and environmental tolerance.

Molecular atlas reveals the tri-sectional spinning mechanism of spider dragline silk

The paper creates a molecular atlas of spider dragline silk production in Trichonephila clavata, revealing a tri-sectional biosynthesis mechanism and cell-type organization in the major ampullate gland.

Chitin and cuticle proteins form the cuticular layer in the spinning duct of silk-spinning arthropods

The paper identifies chitin and cuticle proteins as key components of the cuticular layer in the spinning duct of silkworms, showing their role in silk mechanical properties.

An Array of 60,000 Antibodies for Proteome-Scale Antibody Generation and Target Discovery

The paper develops PETAL, a library of 62,208 mAbs against 15,199 peptides, enabling proteome-scale antibody generation and target discovery across species.

Functional characterization of sensory neuron membrane proteins (SNMPs)

The paper functionally characterizes insect SNMPs using bioinformatics and experimental techniques, identifying a novel SNMP3 gene family and a molecular model for pheromone detection in silkworms.

Programmable single and multiplex base-editing in Bombyx mori using RNA-guided cytidine deaminases

This paper demonstrates the use of RNA-guided cytidine deaminases for programmable single and multiplex base-editing in Bombyx mori with high efficiency and low indel frequency.