Le Sun

High-throughput and genome-scale targeted mutagenesis using CRISPR in a non-model multicellular organism, Bombyx mori

The paper develops a CRISPR-based method to generate a large-scale mutant library in Bombyx mori, identifying genes involved in phenotypic changes and environmental tolerance.

PARylation regulates stress granule dynamics, phase separation, and neurotoxicity of disease-related RNA-binding proteins

This study shows PARylation regulates RNP granule dynamics and neurotoxicity of disease-related RNA-binding proteins, with PARP inhibition reducing neurotoxicity in ALS models.

Programmable single and multiplex base-editing in Bombyx mori using RNA-guided cytidine deaminases

This paper demonstrates the use of RNA-guided cytidine deaminases for programmable single and multiplex base-editing in Bombyx mori with high efficiency and low indel frequency.