Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells
Gabriela Vilema-Enríquez, Robert B. A. Quinlan, Peter Kilfeather, Roberta Mazzone, Saba Saqlain, Irene del Molino del Barrio, Annalidia Donato, Gabriele Corda, Fengling Li, Masoud Vedadi, Andrea Hilary Nemeth, Paul E. Brennan, Richard Wade‐Martins
This study shows that inhibiting SUV4-20 H1 increases frataxin expression in FRDA cells and patient-derived cells, suggesting it as a therapeutic target.
Journal of Biological Chemistry · Oct 7, 2020Peer-reviewedNeuroscience