Masoud Vedadi

Inhibition of Clostridioides difficile-specific DNA adenine methyltransferase CamA by analogs of S-adenosyl-L-methionine

This study identifies SAM analogs that inhibit specific methyltransferases in pathogens and humans, offering potential antivirulence agents and chemical probes.

A chemical probe to modulate human GID4 Pro/N-degron interactions

The paper introduces PFI-7, a chemical probe that inhibits GID4 Pro/N-degron interactions, revealing non-degradative roles of the CTLH complex in human cells.

Inhibition of the SUV4-20 H1 histone methyltransferase increases frataxin expression in Friedreich's ataxia patient cells

This study shows that inhibiting SUV4-20 H1 increases frataxin expression in FRDA cells and patient-derived cells, suggesting it as a therapeutic target.

Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12

MLL1 minimal catalytic complex is a dynamic conformational ensemble susceptible to pharmacological allosteric disruption

The paper investigates the dynamic structure of the MLL1 catalytic complex and shows it can be disrupted by pharmacological agents targeting specific interaction sites.

A Chemical Biology Toolbox for the Study of Protein Methyltransferases and Epigenetic Signaling

The paper presents a chemical probe collection for studying protein methyltransferases, showing their utility in modulating epigenetic marks and affecting T cell differentiation.