Differentiation hierarchy in adult B cell acute lymphoblastic leukemia at clonal resolution
Alec Geßner, Adrien Jolly, Tjeerd Sijmonsma, Yves Matthess, Manuel Kaulich, Stefan Günther, Fabian B. Lang, Florian Buettner, Michael A. Rieger
This study uses barcoding and multiome single-cell data to show a unidirectional differentiation hierarchy in B-ALL with an immature population having high leukemogenic potential.
bioRxiv · Sep 10, 2025 · PreprintCancer Biology