Stefan Günther

Single-Cell Mapping of tRNA Expression Dynamics Across Human Hematopoiesis

This study maps tRNA expression dynamics across human hematopoiesis using sc-STM-seq and identifies tRNAs linked to stemness, differentiation, and cell lineages.

Ischemic injury triggers a protective microglial phenotype in models of Aβ pathology

The paper investigates how ischemic injury affects microglial response to Aβ pathology, finding a protective microglial phenotype that promotes benign Aβ plaque formation.

NAD+ controls circadian rhythmicity during cardiac aging

This study shows that NAD+ supplementation restores circadian rhythms and reverses cardiac aging in mice by reprogramming the diurnal transcriptome.

Reg3β removes aged neutrophils after myocardial infarction

This study identifies REG3β as a factor that removes aged neutrophils after myocardial infarction, promoting inflammation resolution and cardiac repair.

The transaminase-omega-amidase pathway is a redox switch in glutamine metabolism that generates alpha-ketoglutarate

The paper identifies the transaminase-omega-amidase pathway as a redox-sensitive metabolic switch in endothelial glutamine metabolism, showing that NIT2 oxidation inhibits its activity and affects angiogenesis.

Ischemic stroke induces persistent alteration to brain stromal progenitor cells linked to chronic vascular dysfunction

This study shows ischemic stroke causes long-term changes in brain stromal progenitor cells, leading to vascular dysfunction and potential recurrent stroke.

Soluble epoxide hydrolase upregulation in Alzheimer's disease promotes blood-brain barrier dysfunction

This study shows that soluble epoxide hydrolase in astrocytes contributes to vascular instability in Alzheimer's disease, and its deletion reduces vascular amyloid burden and preserves vascular structure.

A microprotein encoded by FERMT3 modulates endothelial cell protein catabolism and induces p53-mediated cell cycle arrest and senescence

Haematopoietic loss of KDM6A impairs cardiac recovery in heartfailure via epigenetic reprogramming of myeloid cells

This study shows that loss of KDM6A in hematopoietic cells impairs cardiac recovery after heart failure by causing epigenetic changes in myeloid cells that increase inflammation and worsen cardiac outcomes.

Ferroptosis governs lymphatic vessel growth and regression

This study identifies ferroptosis as a regulator of lymphatic vessel growth and regression, showing its role in development and injury response through metabolic and lipid pathway mechanisms.

TNF Superfamily Member 14 Drives Post-Influenza Depletion of Alveolar Macrophages Enabling Secondary Pneumococcal Pneumonia

This study identifies TNFSF14 as a driver of alveolar macrophage depletion after influenza, increasing susceptibility to pneumococcal pneumonia, and shows targeting this pathway can reduce disease severity.

Nuclear eNOS interacts with and S-nitrosates ADAR1 to modulate type I interferon signaling and endothelial function.

This study identifies nuclear eNOS's role in modulating ADAR1 activity and type I interferon signaling, linking NO bioavailability to endothelial function and atherogenesis.

Endothelial expression of ZBTB16 protects against cardiac aging

This study identifies ZBTB16 as a critical regulator of endothelial function in aging, showing its protective role against cardiac dysfunction through suppression of pro-fibrotic signaling.

Differentiation hierarchy in adult B cell acute lymphoblastic leukemia at clonal resolution

This study uses barcoding and multiome single-cell data to show a unidirectional differentiation hierarchy in B-ALL with an immature population having high leukemogenic potential.

Loss of multiple micro-RNAs uncovers multi-level restructuring of gene regulation in rodents

The paper investigates the impact of miRNA losses in rodents, showing multi-level gene regulation restructuring and evolutionary consequences.

Erlotinib induces 3D genome rearrangements in lung cancer cells activating tumor suppressor genes through FOXA2-bound Epromoters

Border-zone cardiomyocytes and macrophages contribute to remodeling of the extracellular matrix to promote cardiomyocyte invasion during zebrafish cardiac regeneration

This study identifies border-zone cardiomyocytes and macrophages as key contributors to ECM remodeling that facilitates cardiomyocyte invasion during zebrafish cardiac regeneration.

The transmembrane glycoprotein Gpnmb is required for the immune and fibrotic responses during zebrafish heart regeneration

This study identifies Gpnmb as a critical regulator of immune and fibrotic responses during zebrafish heart regeneration, showing its role in macrophage function and ECM regulation.

Long non-coding RNAs direct the SWI/SNF complex to cell-specific enhancers

This study identifies long non-coding RNAs (lncRNAs) as guides for the SWI/SNF complex to cell-specific enhancers, revealing a mechanism for chromatin accessibility and gene expression control.

3D genome organization during TGFB-induced transcription requires nuclear microRNA and G-quadruplexes

The paper shows that nuclear miR-9 is required for chromatin features and promoter-super-enhancer looping during TGFB1-induced transcriptional activation.

flt1 inactivation promotes zebrafish cardiac regeneration by enhancing endothelial activity and limiting the fibrotic response

This study shows that inactivating flt1 in zebrafish enhances cardiac regeneration by improving vascularization and reducing fibrosis.

Metabolic alterations drive inflammatory phenotypes in CHIP-associated heart failure

This study shows that DNMT3A mutations in CHIP lead to metabolic changes in macrophages that drive inflammation, and targeting these changes can improve heart failure outcomes.

A common gene signature of the right ventricle in failing rat and human hearts

The paper identifies a conserved gene signature associated with right ventricular failure in both rat and human hearts through transcriptomic analysis and validation.

The homeobox transcription factor DUXBL controls exit from totipotency

This study identifies DUXBL as a key factor promoting the silencing of the 2C transcriptional program during exit from totipotency.

The aging-induced long non-coding RNA MIRIAL controls endothelial cell and mitochondrial function

This paper identifies MIRIAL as an aging-induced lncRNA that regulates endothelial quiescence and mitochondrial function through a novel triplex mechanism.

The endothelial-specific LINC00607 mediates endothelial angiogenic function

This study identifies LINC00607 as an endothelial-specific lncRNA that supports angiogenic function by interacting with BRG1 to regulate chromatin accessibility and ERG target gene transcription.

HIF1α-AS1 is a DNA:DNA:RNA triplex-forming lncRNA interacting with the HUSH complex

The paper identifies HIF1α-AS1 as a DNA:DNA:RNA triplex-forming lncRNA that interacts with the HUSH complex to repress gene expression and modulates angiogenesis in pulmonary hypertension.

The developing epicardium regulates cardiac chamber morphogenesis by promoting cardiomyocyte growth

This study shows that epicardial impairment in zebrafish leads to smaller ventricles due to defective cardiomyocyte growth, highlighting the role of FGF and VEGF signaling in cardiac morphogenesis.

The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression

This study identifies Snai1's role in maintaining myocardial wall integrity by repressing intermediate filament gene expression in zebrafish.

Positioning of nucleosomes containing γ-H2AXprecedes active DNA demethylation and transcription initiation

The paper shows that HMGA2 induces DNA nicks required for nucleosome incorporation containing H2A.X, which is necessary for DNA demethylation and transcription initiation.