Yves Matthess

This study identifies functional enhancer dependencies in pediatric AML using an integrative approach, revealing H-ME as an RNA-independent regulator of MYB.

This study maps tRNA expression dynamics across human hematopoiesis using sc-STM-seq and identifies tRNAs linked to stemness, differentiation, and cell lineages.

The paper maps variant, enhancer, and gene function in primary human CD4+ T cells by combining Perturb-seq of regulatory elements and genes, identifying CRE-gene pairs and linking variants to disease-related programs.

This paper constructs a comprehensive annotated dataset of human E3 ligases and uses a hierarchical classification framework to analyze their functional and structural relationships.

This study identifies ferroptosis as a regulator of lymphatic vessel growth and regression, showing its role in development and injury response through metabolic and lipid pathway mechanisms.

This study uses barcoding and multiome single-cell data to show a unidirectional differentiation hierarchy in B-ALL with an immature population having high leukemogenic potential.