Author

Alec Geßner

Goethe University Frankfurt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:multiome· 1

Frequent Co-Authors

Michael A. RiegeriD· 2 shared Adrien JollyiD· 1 shared Andreas WeigertiD· 1 shared Ernst H. K. StelzeriD· 1 shared Fabian B. LangiD· 1 shared Florian BuettneriD· 1 shared Francesco PampaloniiD· 1 shared Geoffroy AndrieuxiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Michael A. RiegerORCID

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2 papers

Recent·Most cited

Inhibition of IAPs induces programmed cell death and inflammatory signaling in patient-derived metastatic breast cancer organoids

Kaja Nicole Wächtershäuser, Jana V. Schneider, Alec Geßner, Geoffroy Andrieux, Ivan-Maximilano Kur, Nadine Duschek, Andreas Weigert, Melanie Boerries, Michael A. Rieger, Ernst H. K. Stelzer, Francesco Pampaloni, Sjoerd J. L. van Wijk

This study shows that Smac mimetics induce apoptosis in breast cancer organoids and that necroptosis, associated with inflammation, can be inhibited by LUBAC inhibitors.

Signal Transduction and Targeted Therapy · Jun 1, 2026Peer-reviewedCancer Biology

Differentiation hierarchy in adult B cell acute lymphoblastic leukemia at clonal resolution

Alec Geßner, Adrien Jolly, Tjeerd Sijmonsma, Yves Matthess, Manuel Kaulich, Stefan Günther, Fabian B. Lang, Florian Buettner, Michael A. Rieger

This study uses barcoding and multiome single-cell data to show a unidirectional differentiation hierarchy in B-ALL with an immature population having high leukemogenic potential.

bioRxiv · Sep 10, 2025 · PreprintCancer Biology