This study links polygenic scores for QT interval to changes in Kv11.1 protein interactions in hiPSC-CMs, revealing connections between genetic variants and endocytic trafficking mechanisms.

Molecular & Cellular Proteomics · Sep 11, 2026Peer-reviewedGenomics

Structural Evaluation of RYR2-CPVT Missense Variants and Continuous Bayesian Estimates of their Penetrance

Kohei Yamauchi, Matthew Ku, Devyn Mitchell, Alex Shen, Kundivy Dauda, Loren R. Vanags, Jeffrey Schmeckpeper, Björn C. Knollmann, Matthew J. O’Neill, Brett M. Kroncke

The paper evaluates RYR2-CPVT missense variants using Bayesian penetrance analysis and finds it outperforms existing tools.

medRxiv · Mar 20, 2025 · PreprintGenetic & Genomic Medicine

EFP Analyzer: A fast, accurate, and easy-to-teach program for analyzing Extracellular Field Potentials from iPSC-derived cardiomyocytes

Nidhi Patel, Alex Shen, Yuko Wada, Marcia A. Blair, Devyn Mitchell, Loren R. Vanags, Suah Woo, Matthew Ku, Kundivy Dauda, William Morris, Minjoo Yang, Björn C. Knollmann, Dan M. Roden, Joe-Elie Salem, Andrew Michael Glazer, Brett M. Kroncke

The paper introduces EFP-Analyzer, a software tool for analyzing extracellular field potentials from iPSC-derived cardiomyocytes, showing it accurately measures intervals and detects drug or mutation effects.

Scientific Reports · Mar 15, 2025Peer-reviewedPharmacology & Toxicology