Author

Lea A. Barny

Vanderbilt UniversityORCID 0009-0006-3300-638XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 3 Systems Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Assay:proteomics· 6 Organism:human· 5 Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Research Focus:differential expression· 2 Approach:statistical model· 2 Organism:mouse· 1 Research Focus:software / tool· 1

Frequent Co-Authors

Lars PlateiD· 6 shared Björn C. KnollmanniD· 2 shared Christian L. EglyiD· 2 shared Jake N HermansoniD· 2 shared Minsoo KimiD· 2 shared Sarah K. Garcia· 2 shared Aiden Houcek· 1 shared Anjaparavanda P. NareniD· 1 shared

Activity by Year

2024-2026 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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6 shared papersBiochemistry

Lars PlateORCID

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

GenomicsMolecular & Cellular ProteomicsPeer-reviewedSep 11, 2026

Kv11.1 (hERG) Protein Interaction Networks Connect Endocytic Trafficking to Polygenic Influences on Cardiac Repolarization

Christian L. Egly, Lea A. Barny, Suah Woo…·Brett M. Kroncke

This study links polygenic scores for QT interval to changes in Kv11.1 protein interactions in hiPSC-CMs, revealing connections between genetic variants and endocytic trafficking mechanisms.

DOI 10.1016/j.mcpro.2026.101656

humanproteomics

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BiochemistrybioRxivPreprintAug 11, 2025

Proteostasis and Unfolded Protein Response Dynamics in Human Neuron and Mouse Glia Co-culture Reveal Cell-Specific Aging Responses

Lea A. Barny, Sarah K. Garcia, Aiden Houcek…·Lars Plate

This study uses DIA proteomics to analyze age-related changes in proteostasis and UPR dynamics in human neurons and mouse glia co-cultures, revealing cell-type-specific aging responses.

2 citations

humanmouse

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Systems BiologyMolecular & Cellular ProteomicsPeer-reviewedJul 15, 2025

Dissecting Branch-Specific Unfolded Protein Response Activation in Drug-Tolerant BRAF-Mutant Melanoma using Data-Independent Acquisition Mass Spectrometry

Lea A. Barny, Jake N Hermanson, Sarah K. Garcia…·Lars Plate

This study identifies branch-specific UPR proteomic targets in BRAF-mutant melanoma using DIA LC-MS, revealing differential XBP1s regulation linked to drug tolerance.

7 citations

humanproteomics

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BiochemistryACS Chemical BiologyPeer-reviewedJun 20, 2025

Photoaffinity ligand of Cystic Fibrosis corrector VX-445 identifies SCCPDH as an off-target

Minsoo Kim, Kwangho Kim, Jesun Lee…·Lars Plate

The paper identifies SCCPDH as an off-target of VX-445 using a photoaffinity ligand and chemoproteomics, showing metabolic dysregulation and potential clinical implications.

2 citations

humanproteomics

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Systems BiologyJournal of Proteome ResearchPeer-reviewedMay 27, 2025

Development of an Adaptive, Economical, and Easy-to-Use SP3-TMT Automated Sample Preparation Workflow for Quantitative Proteomics

Jake N Hermanson, Lea A. Barny, Lars Plate

The paper develops an automated SP3-TMT sample preparation workflow for proteomics, showing it matches manual methods in performance while improving throughput, cost, and error reduction.

4 citations

proteomicsexperimental assay

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BiochemistryJournal of Biological ChemistryPeer-reviewedJun 12, 2024

The proteostasis interactomes of trafficking-deficient KV11.1 variants associated with Long QT Syndrome and pharmacological chaperone rescue

Christian L. Egly, Lea A. Barny, Tri Q. Do…·Lars Plate

The paper identifies proteostasis interactomes of trafficking-deficient KV11.1 variants and shows pharmacological chaperone rescue of proteostasis network alterations in LQTS-associated variants.

5 citations

humanproteomics

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